Research Catalog

Title

Fundamental concepts of bioinformatics / Dan E. Krane, Michael L. Raymer.

Author

Krane, Dan E.

Publication

San Francisco : Benjamin Cummings, [2003], ©2003.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Raymer, Michael L

Subject

Bioinformatics

Bibliography (note)

• Includes bibliographical references and index.

Contents

• 1. Molecular Biology and Biological Chemistry -- The Genetic Material -- Gene Structure and Information Content -- Protein Structure and Function -- The Nature of Chemical Bonds -- Molecular Biology Tools -- Genomic Information Content -- 2. Data Searches and Pairwise Alignments -- Dot Plots -- Simple Alignments -- Gaps -- Scoring Matrices -- Dynamic Programming: The Needleman and Wunsch Algorithm -- Global and Local Alignments -- Database Searches -- Multiple Sequence Alignments -- 3. Substitution Patterns -- Patterns of Substitutions within Genes -- Estimating Substitution Numbers -- Variations in Evolutionary Rates between Genes -- Molecular Clocks -- Evolution in Organelles -- 4. Distance-Based Methods of Phylogenetics -- History of Molecular Phylogenetics -- Advantages to Molecular Phylogenies -- Phylogenetic Trees -- Distance Matrix Methods -- Maximum Likelihood Approaches -- Multiple Sequence Alignments --
• 5. Character-Based Methods of Phylogenetics -- Parsimony -- Inferred Ancestral Sequences -- Strategies for Faster Searches -- Consensus Trees -- Tree Confidence -- Comparison of Phylogenetic Methods -- Molecular Phylogenies -- 6. Genomics and Gene Recognition -- Prokaryotic Genomes -- Prokaryotic Gene Structure -- GC Content in Prokaryotic Genomes -- Prokaryotic Gene Density -- Eukaryotic Genomes -- Eukaryotic Gene Structure -- Open Reading Frames -- GC Content in Eukaryotic Genomes -- Gene Expression -- Transposition -- Repetitive Elements -- Eukaryotic Gene Density -- 7. Protein and RNA Structure Prediction -- Amino Acids -- Polypeptide Composition -- Secondary Structure -- Tertiary and Quaternary Structure -- Algorithms for Modeling Protein Folding -- Structure Prediction -- Predicting RNA Secondary Structures -- 8. Proteomics -- From Genomes to Proteomes -- Protein Classification -- Experimental Techniques --
• Inhibitors and Drug Design -- Ligand Screening -- X-Ray Crystal Structures -- NMR Structures -- Empirical Methods and Prediction Techniques -- Post-Translational Modification Prediction. App. 1. A Gentle Introduction to Computer Programming and Data Structures -- App. 2. Enzyme Kinetics -- App. 3. Sample Programs in Perl.

ISBN

0805346333 (pbk. : alk. paper)

LCCN

2002012574

OCLC

• 50323112
• ocm50323112
• SCSB-4346963

Owning Institutions

Columbia University Libraries